Biosimilar App Notes & Case Studies
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Review Of Applications And Processes In Fixed-Bed Bioreactors
5/6/2024
Gain insights and guidelines for developing new processes in this review evaluating publications on the applications of single-use, scalable fixed-bed bioreactors for adherent cell culture processes.
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Impact Of Glycosylation On The Effector Functions Of Monoclonal Antibodies
2/9/2024
In an example using rituximab and its biosimilars, explore the significance of minor differences of glycosylation in antibodies and its impact on their properties and functionality.
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How Membrane Prefilters Enhance Bioprocessing Efficiency
12/14/2022
Explore studies that highlight the benefits of prefiltration for increasing throughput capacity of sterilizing-grade filters challenged with streams containing a wide range of particle size distributions.
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Natural Killer Cells Manufacturing
7/22/2022
Follow the feasibility of xeno‑free NK cell expansion, closure of key unit operations, and how future work could focus on fine‑tuning each step to generate a robust, scalable process.
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Process Control And Performance Of A Virus Filtration System
1/12/2023
Discover a single-use automated filtration system designed to deliver robust process control and integrity assurance during the critical purification step. Explore its design features, processing control, and more.
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Depth Filtration Devices For Cell Cultures, Fermentation Broths, And Cell Lysates
3/27/2023
Typically, devices containing depth media filters can offer more efficient filtration. Browse depth filtration products and devices for the downstream processing of cell culture solutions, fermentation broths, and lysates.
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Accelerating Bulk Harvest Testing Using A CHO Animal Origin Free Virus Panel
10/19/2023
Here, we describe the design and performance of a degenerate PCR-based approach to broad virus screening that can be used in testing bulk harvest material derived from CHO cells.
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Protein L Affinity Resin Is Ready To Move To Manufacturing
7/12/2023
Discover a protein L affinity chromatography resin that is well suited for use in biomanufacturing and offers increased binding capacities compared to other resins.
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Scalability And Performance Of Single-Use Bioreactors
8/1/2023
Here, we provide scalability data as a guide for process development and cross-scale performance expectations and characterize performance attributes of the impeller, spargers, Ultimus® film, and sensors.
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Lentiviral Vector Production Using Single-Use Bioreactors
5/6/2024
Here, we outline a scalable and robust upstream process developed for LVV production of HEK293T cells and demonstrate how to expand HEK293T suspension cells.